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An organ-on-a-chip (OOC) in vitro device such as a microfluidic chip with microfluidic flow channels populated by living cells provides an accurate non-animal based high-throughput alternative to traditional lab animal tests. PimBio organ-on-a-chip device allows a user to perform cell-based assays under in vivo like 3D conditions and is especially suited to the in vitro simulation of physiological cellular microenvironment involving interstitial flow biomechanical stimulation. Our organ-on-a-chip platform with standard microscope slide dimensions is a gravity driven microfluidic system compatible with any laboratory pumping system.

PimBio B.V. is focused on development and small series manufacturing microfluidic devices for bioengineering physiologically relevant in vitro models for different applications. PimBio supports the 3Rs, the guiding principles of reduction, refinement and replacement of animal experiments.

Applications:

• Provide an accurate non-animal based high-throughput alternative to traditional lab animal tests
• Test the effects of new drug candidates for safety and efficacy in human tissues
• Help scientists elucidate how tissues respond to new drug candidates
• Develop vaccines and drugs to counter bioterrorism threats
• Test the safety and efficacy of cosmetics, chemicals, food ingredients etc.
• Ensure better regulatory decision-making


PimBio organ-on-a-chip microfluidic chip device

About PimBio


PimBio is focused on development and manufacturing of microfluidic devices for bioengineering physiologically relevant in vitro models for different applications. PimBio supports the 3Rs, the guiding principles of reduction, refinement and replacement of animal experiments … Read more

Products


Our Design and Prototyping Studio offers development of  new  microfluidic devices for bioengineering physiologically relevant living tissue for academic and industry partners.

Collaboration


PimBio works with academic and industry partners to collaboratively develop devices and in vitro models which have unique applications for disease modelling, testing, drug discovery and development. A collaborative relationship allows an exchange of expertise which benefits all parties and ultimately will have positive impacts on human health … Read more

Multimedia


pimbio microfluidic chip devices organ-on-chip

News


€0,5M for iPSC-based NMJ-on-a-chip model

Approximately 200.000 Dutch patients suffer from neuromuscular disorders (NMDs). Neuromuscular junctions (NMJs) are highly specialized structures that enable motor neurons to communicate with muscle fibers to establish muscle contraction. NMJ pathophysiology underlies muscle dysfunction in a range of NMDs such as amyotrophic lateral sclerosis, myasthenia gravis and Duchenne muscular dystrophy. The recent development of advanced … Read more

€1,3M funding to CONNECT the Blood-Brain Barrier to Cerebral Organoids

  The brain is the most complex organ in the human body. Today, it remains a challenge to effectively treat patients suffering from a brain disorder such as Alzheimer’s disease, multiple sclerosis, or stroke. A brain disorder has a huge impact on patients, their caretakers, and society but effective drugs remain an unmet clinical need. … Read more

PimBio receives a grant for feasibility study

PimBio has received financial support from the Dutch Ministry of Economic Affairs and Climate under the program “De Subsidieregeling MKB Innovatiestimulering Topsectoren Zuid-Nederland 2015”. The project covers feasibility study for additive manufacturing microfluidica for cell culture designated with the acronym ‘ADAM’. Goal of the project is to obtain insight in the technological feasibility to prototype … Read more

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